|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:tyrosine-protein_kinase_TYK2
JAK4
|
|
gptkbp:associatedWith
|
gptkb:systemic_lupus_erythematosus
autoimmune diseases
psoriasis
immunodeficiency
inflammatory bowel disease
|
|
gptkbp:discoveredBy
|
gptkb:Darnell_JE_Jr.
|
|
gptkbp:discoveredIn
|
1990
|
|
gptkbp:encodedBy
|
TYK2 gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000105397
|
|
gptkbp:expressedIn
|
hematopoietic cells
immune cells
|
|
gptkbp:fullName
|
gptkb:Tyrosine_kinase_2
|
|
gptkbp:function
|
non-receptor tyrosine kinase
protein tyrosine kinase activity
|
|
gptkbp:gene
|
gptkb:TYK2
|
|
gptkbp:HGNC_ID
|
HGNC:12440
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Tyk2
|
|
gptkbp:interactsWith
|
gptkb:STAT1
gptkb:JAK1
gptkb:STAT2
gptkb:STAT3
gptkb:IL-12_receptor
gptkb:IFNAR1
IL-23 receptor
|
|
gptkbp:involvedIn
|
immune response
interferon signaling
cytokine signaling
|
|
gptkbp:locatedOnChromosome
|
gptkb:19p13.2
|
|
gptkbp:location
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:memberOf
|
gptkb:Janus_kinase_family
|
|
gptkbp:molecularWeight
|
~134 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
4OLI
6NZU
|
|
gptkbp:phosphorylates
|
gptkb:STAT1
gptkb:STAT2
gptkb:STAT4
gptkb:STAT3
Y1054
Y1055
|
|
gptkbp:RefSeq
|
NM_003331
|
|
gptkbp:target
|
gptkb:BMS-986165
gptkb:deucravacitinib
|
|
gptkbp:UniProtID
|
P29597
|
|
gptkbp:bfsParent
|
gptkb:TYK2
|
|
gptkbp:bfsLayer
|
8
|