Statements (53)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
medical condition
|
| gptkbp:affects |
adults
children elderly |
| gptkbp:alsoKnownAs |
gptkb:CRS
gptkb:cytokine_storm |
| gptkbp:associatedWith |
gene therapy
infections monoclonal antibody therapy |
| gptkbp:canBeFatal |
yes
|
| gptkbp:canBeSevere |
yes
|
| gptkbp:cause |
gptkb:acute_respiratory_distress_syndrome
death multi-organ failure |
| gptkbp:causedBy |
overactivation of immune system
|
| gptkbp:characterizedBy |
systemic inflammatory response
|
| gptkbp:complication |
gene therapy
stem cell transplantation biologic therapy |
| gptkbp:diagnosedBy |
clinical assessment
laboratory tests elevated cytokine levels |
| gptkbp:firstDescribed |
1990s
|
| https://www.w3.org/2000/01/rdf-schema#label |
Cytokine Release Syndrome
|
| gptkbp:ICD-10_code |
D89.83
|
| gptkbp:monitors |
vital signs
cytokine levels organ function tests |
| gptkbp:notableCytokinesInvolved |
gptkb:interferon-gamma
gptkb:interleukin-2 gptkb:interleukin-6 gptkb:interleukin-10 gptkb:tumor_necrosis_factor_alpha |
| gptkbp:riskFactor |
leukemia
infection immunotherapy |
| gptkbp:symptom |
gptkb:hypoxia
fever nausea vomiting fatigue headache hypotension tachycardia organ dysfunction myalgia |
| gptkbp:treatment |
gptkb:tocilizumab
supportive care oxygen therapy corticosteroids vasopressors |
| gptkbp:bfsParent |
gptkb:CRS
|
| gptkbp:bfsLayer |
6
|