Cytokine Release Syndrome

URI: https://gptkb.org/entity/Cytokine_Release_Syndrome

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:medical_condition
gptkbp:affects	adults children elderly
gptkbp:alsoKnownAs	gptkb:CRS gptkb:cytokine_storm
gptkbp:associatedWith	gptkb:gene_therapy infections monoclonal antibody therapy
gptkbp:canBeFatal	yes
gptkbp:canBeSevere	yes
gptkbp:cause	gptkb:death gptkb:acute_respiratory_distress_syndrome multi-organ failure
gptkbp:causedBy	overactivation of immune system
gptkbp:characterizedBy	systemic inflammatory response
gptkbp:complication	gptkb:gene_therapy gptkb:biologic_therapy stem cell transplantation
gptkbp:diagnosedBy	clinical assessment laboratory tests elevated cytokine levels
gptkbp:firstDescribed	1990s
gptkbp:ICD-10_code	D89.83
gptkbp:monitors	vital signs cytokine levels organ function tests
gptkbp:notableCytokinesInvolved	gptkb:interferon-gamma gptkb:interleukin-2 gptkb:interleukin-6 gptkb:interleukin-10 gptkb:tumor_necrosis_factor_alpha
gptkbp:riskFactor	gptkb:leukemia gptkb:immunotherapy infection
gptkbp:symptom	gptkb:hypoxia fever nausea vomiting fatigue headache hypotension tachycardia organ dysfunction myalgia
gptkbp:treatment	gptkb:tocilizumab supportive care oxygen therapy corticosteroids vasopressors
gptkbp:bfsParent	gptkb:CRS
gptkbp:bfsLayer	6
https://www.w3.org/2000/01/rdf-schema#label	Cytokine Release Syndrome