|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alsoKnownAs
|
gptkb:ADAM17
tumor necrosis factor-alpha converting enzyme
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
rheumatoid arthritis
|
|
gptkbp:biologicalProcess
|
cell signaling
inflammatory response
protein ectodomain shedding
|
|
gptkbp:cofactor
|
zinc
|
|
gptkbp:discoveredBy
|
Michael D. Black
|
|
gptkbp:encodedBy
|
ADAM17 gene
|
|
gptkbp:enzymeClassification
|
EC 3.4.24.86
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:function
|
cleaves membrane proteins
releases TNF-alpha
|
|
gptkbp:gene
|
gptkb:ADAM17
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TACE (ADAM17)
|
|
gptkbp:inhibitedBy
|
TAPI-1
|
|
gptkbp:locatedOnChromosome
|
chromosome 2
|
|
gptkbp:memberOf
|
ADAM family
|
|
gptkbp:molecularWeight
|
~100 kDa
|
|
gptkbp:OMIM
|
603639
|
|
gptkbp:orthologInMouse
|
Adam17
|
|
gptkbp:PDB
|
3E8R
|
|
gptkbp:product
|
metalloprotease
|
|
gptkbp:regulates
|
activated by phosphorylation
regulated by TIMP3
|
|
gptkbp:significance
|
target for anti-inflammatory drugs
|
|
gptkbp:structure
|
transmembrane protein
|
|
gptkbp:substrate
|
EGFR ligands
pro-TNF-alpha
|
|
gptkbp:UniProtID
|
P78536
|
|
gptkbp:bfsParent
|
gptkb:tumor_necrosis_factor_alpha
|
|
gptkbp:bfsLayer
|
6
|