phosphoinositide 3-kinase (PI3K) complex

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:activatedBy	gptkb:G_protein-coupled_receptors gptkb:receptor_tyrosine_kinases
gptkbp:associatedWith	gptkb:cancer gptkb:diabetes immune response
gptkbp:catalyzes	conversion of PIP2 to PIP3
gptkbp:downstreamOf	insulin signaling growth factor signaling
gptkbp:encodedBy	gptkb:PIK3CA_gene gptkb:PIK3CB_gene gptkb:PIK3CD_gene gptkb:PIK3CG_gene
gptkbp:function	phosphorylation of phosphoinositides
gptkbp:hasIsoform	gptkb:Class_III_PI3K gptkb:Class_II_PI3K gptkb:Class_I_PI3K
https://www.w3.org/2000/01/rdf-schema#label	phosphoinositide 3-kinase (PI3K) complex
gptkbp:inhibitedBy	gptkb:LY294002 gptkb:wortmannin
gptkbp:involvedIn	cell proliferation cell survival cell growth cell signaling metabolism regulation
gptkbp:locale	gptkb:cytoplasm gptkb:plasma_membrane
gptkbp:regulates	gptkb:AKT_signaling_pathway gptkb:mTOR_pathway
gptkbp:subunit	p110 catalytic subunit p85 regulatory subunit
gptkbp:bfsParent	gptkb:p110-alpha gptkb:phosphatidylinositol-4,5-bisphosphate_3-kinase_catalytic_subunit_alpha_isoform gptkb:phosphatidylinositol_4,5-bisphosphate_3-kinase_catalytic_subunit_alpha
gptkbp:bfsLayer	6