AKT signaling pathway

GPTKB entity

Statements (49)
Predicate Object
gptkbp:instanceOf signaling molecule
gptkbp:activatedBy gptkb:insulin
gptkb:receptor_tyrosine_kinases
cytokines
growth factors
gptkbp:alsoKnownAs gptkb:PI3K/AKT_pathway
gptkbp:component gptkb:AKT_(protein_kinase_B)
gptkb:PI3K_(phosphoinositide_3-kinase)
gptkb:PTEN_(phosphatase_and_tensin_homolog)
PDK1 (3-phosphoinositide-dependent protein kinase-1)
gptkbp:downstreamOf gptkb:TSC2
gptkb:BAD_(Bcl-2-associated_death_promoter)
gptkb:FOXO_transcription_factors
gptkb:MDM2
gptkb:mTOR
GSK3 (glycogen synthase kinase 3)
gptkbp:dysregulationAssociatedWith gptkb:cancer
gptkb:diabetes
neurodegenerative diseases
cardiovascular diseases
gptkbp:firstDescribed 1991
https://www.w3.org/2000/01/rdf-schema#label AKT signaling pathway
gptkbp:inhibitedBy gptkb:PTEN
gptkbp:involves gptkb:PI(3,4,5)P3
gptkb:PI(4,5)P2
lipid second messengers
phosphorylation cascade
gptkbp:location gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
gptkbp:modulatedBy monoclonal antibodies
genetic mutations
small molecule inhibitors
gptkbp:phosphorylates multiple substrates
gptkbp:regulates apoptosis
cell proliferation
cell survival
angiogenesis
cell growth
cell migration
cell metabolism
gptkbp:studiedIn gptkb:pharmacy
cell biology
oncology
endocrinology
gptkbp:targetOfDrug gptkb:cancer
metabolic disorders
gptkbp:bfsParent gptkb:protein
gptkbp:bfsLayer 4