|
gptkbp:instanceOf
|
gptkb:signaling_molecule
|
|
gptkbp:activatedBy
|
gptkb:insulin
gptkb:receptor_tyrosine_kinases
cytokines
growth factors
|
|
gptkbp:alsoKnownAs
|
gptkb:PI3K/AKT_pathway
|
|
gptkbp:component
|
gptkb:AKT_(protein_kinase_B)
gptkb:PI3K_(phosphoinositide_3-kinase)
gptkb:PTEN_(phosphatase_and_tensin_homolog)
PDK1 (3-phosphoinositide-dependent protein kinase-1)
|
|
gptkbp:downstreamOf
|
gptkb:TSC2
gptkb:BAD_(Bcl-2-associated_death_promoter)
gptkb:FOXO_transcription_factors
gptkb:MDM2
gptkb:mTOR
GSK3 (glycogen synthase kinase 3)
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:cancer
gptkb:diabetes
neurodegenerative diseases
cardiovascular diseases
|
|
gptkbp:firstDescribed
|
1991
|
|
gptkbp:inhibitedBy
|
gptkb:PTEN
|
|
gptkbp:involves
|
gptkb:PI(3,4,5)P3
gptkb:PI(4,5)P2
lipid second messengers
phosphorylation cascade
|
|
gptkbp:location
|
gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:modulatedBy
|
monoclonal antibodies
genetic mutations
small molecule inhibitors
|
|
gptkbp:phosphorylates
|
multiple substrates
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
cell survival
angiogenesis
cell growth
cell migration
cell metabolism
|
|
gptkbp:studiedIn
|
gptkb:pharmacy
cell biology
oncology
endocrinology
|
|
gptkbp:targetOfDrug
|
gptkb:cancer
metabolic disorders
|
|
gptkbp:bfsParent
|
gptkb:PI3K_gamma
gptkb:p110α
gptkb:p110-alpha
gptkb:phosphoinositide_3-kinase_family
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
AKT signaling pathway
|