phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha

URI: https://gptkb.org/entity/phosphatidylinositol_4,5-bisphosphate_3-kinase_catalytic_subunit_alpha
GPTKB entity
Statements (47)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:phosphatidylinositol-4,5-bisphosphate_3-kinase_catalytic_subunit_alpha_isoform
gptkb:PI3-kinase_p110_alpha
gptkb:PI3K_alpha
gptkbp:associatedWith gptkb:cancer
gptkb:endometrial_cancer
colorectal cancer
gptkbp:biologicalProcess kinase activity
gptkbp:discoveredBy gptkb:Lewis_Cantley
gptkbp:Entrez_Gene_ID GC03M179504
gptkbp:enzymeCommissionNumber 2.7.1.153
gptkbp:expressedIn many tissues
gptkbp:firstDescribed 1990s
gptkbp:function catalyzes phosphorylation of phosphatidylinositol 4,5-bisphosphate
involved in PI3K/AKT signaling pathway
gptkbp:gene gptkb:PIK3CA
gptkbp:HGNC_ID 8975
https://www.w3.org/2000/01/rdf-schema#label phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha
gptkbp:interactsWith regulatory subunit p85
gptkbp:length 1068
gptkbp:locatedOnChromosome 3q26.32
gptkbp:location gptkb:cytoplasm
gptkb:plasma_membrane
gptkbp:molecularWeight 124 kDa
gptkbp:mutationAssociatedWith E542K
E545K
H1047R
gptkbp:OMIM 171834
gptkbp:organism gptkb:Homo_sapiens
gptkbp:phosphorylates gptkb:phosphatidylinositol_4,5-bisphosphate_(PIP2)
gptkbp:product gptkb:phosphatidylinositol_3,4,5-trisphosphate_(PIP3)
gptkbp:RefSeq NP_006209.2
gptkbp:role cell proliferation
cell survival
metabolism
angiogenesis
cell growth
oncogenesis
gptkbp:subunit gptkb:phosphoinositide_3-kinase_(PI3K)_complex
gptkbp:target gptkb:alpelisib
gptkb:buparlisib
gptkb:copanlisib
gptkb:idelalisib
PI3K inhibitors
gptkbp:UniProtID gptkb:P42336
gptkbp:bfsParent gptkb:PIK3CA
gptkbp:bfsLayer 5