Statements (22)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:component |
gptkb:phosphoinositide_3-kinase_(PI3K)_complex
|
| gptkbp:encodedBy |
gptkb:PIK3CA_gene
|
| gptkbp:formsComplexWith |
p85 regulatory subunit
|
| gptkbp:function |
catalytic subunit of PI3K
|
| https://www.w3.org/2000/01/rdf-schema#label |
p110-alpha
|
| gptkbp:involvedIn |
cell proliferation
cell survival metabolism cell growth |
| gptkbp:location |
gptkb:cytoplasm
gptkb:plasma_membrane |
| gptkbp:molecularWeight |
110 kDa
|
| gptkbp:mutationAssociatedWith |
gptkb:cancer
gptkb:endometrial_cancer colorectal cancer |
| gptkbp:phosphorylates |
gptkb:phosphatidylinositol_(4,5)-bisphosphate_(PIP2)
|
| gptkbp:produces |
gptkb:phosphatidylinositol_(3,4,5)-trisphosphate_(PIP3)
|
| gptkbp:regulates |
gptkb:AKT_signaling_pathway
|
| gptkbp:target |
PI3K inhibitors
|
| gptkbp:bfsParent |
gptkb:PIK3CA
|
| gptkbp:bfsLayer |
5
|