|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:phosphoinositide-3-kinase_catalytic_subunit_gamma
PI3KCG
p110-gamma
|
|
gptkbp:associatedWith
|
asthma
chronic obstructive pulmonary disease
rheumatoid arthritis
|
|
gptkbp:discoveredBy
|
Jean-Philippe Kinet group
|
|
gptkbp:encodes
|
gptkb:phosphatidylinositol-4,5-bisphosphate_3-kinase_catalytic_subunit_gamma_isoform
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000105851
5294
|
|
gptkbp:expressedIn
|
gptkb:leukocytes
gptkb:cancer
heart
spleen
|
|
gptkbp:firstDescribed
|
1997
|
|
gptkbp:function
|
catalytic subunit of class I PI3K gamma
|
|
gptkbp:GO_term
|
GO:0007165
GO:0008286
GO:0005942
|
|
gptkbp:HGNC_ID
|
8977
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PIK3CG gene
|
|
gptkbp:involvedIn
|
signal transduction
cell migration
inflammation
immune response
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_7
7q22.3
|
|
gptkbp:MIM_number
|
602838
|
|
gptkbp:mutationAssociatedWith
|
immune system disorders
|
|
gptkbp:OMIM_entry
|
602838
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Pik3cg
|
|
gptkbp:product
|
gptkb:PI3K_gamma
|
|
gptkbp:proteinFamily
|
gptkb:PI3K/PI4K_domain
C2 domain
Pkinase domain
PI3/PI4-kinase family
|
|
gptkbp:RefSeq
|
NM_002649
|
|
gptkbp:regulates
|
inflammatory response
chemotaxis
|
|
gptkbp:target
|
gptkb:IPI-549
AS-605240
CZC24832
pharmacological inhibitors
Duvelisib
Idelalisib
|
|
gptkbp:UniProtID
|
gptkb:P48736
|
|
gptkbp:bfsParent
|
gptkb:Class_IB_PI3K
gptkb:PI3K_gamma
gptkb:p110γ
gptkb:phosphatidylinositol-4,5-bisphosphate_3-kinase_catalytic_subunit_gamma_isoform
gptkb:phosphoinositide_3-kinase_complex
|
|
gptkbp:bfsLayer
|
6
|