|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:CD120b
gptkb:TNFR2
gptkb:TNFBR
p75
p80
|
|
gptkbp:associatedWith
|
gptkb:cancer
autoimmune diseases
inflammatory diseases
|
|
gptkbp:discoveredBy
|
researchers in the late 1980s
|
|
gptkbp:encodes
|
Tumor necrosis factor receptor type 2
|
|
gptkbp:Entrez_Gene_ID
|
7133
ENSG00000028137
|
|
gptkbp:expressedIn
|
gptkb:neurons
endothelial cells
immune cells
|
|
gptkbp:fullName
|
gptkb:Tumor_necrosis_factor_receptor_superfamily_member_1B
|
|
gptkbp:function
|
involved in apoptosis
involved in cell survival
involved in immune regulation
mediates the majority of the metabolic effects of TNF-alpha
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasCytoplasmicDomain
|
true
|
|
gptkbp:hasExtracellularDomain
|
true
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
11917
|
|
gptkbp:interactsWith
|
gptkb:TNF-alpha
gptkb:TRAF2
gptkb:TRAF1
|
|
gptkbp:locatedOnChromosome
|
gptkb:1p36.22
|
|
gptkbp:MIMNumber
|
191191
|
|
gptkbp:OMIM
|
191191
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Tnfrsf1b
|
|
gptkbp:proteinFamily
|
gptkb:TNF_receptor_superfamily
|
|
gptkbp:receptorFor
|
gptkb:tumor_necrosis_factor_alpha_(TNF-α)
|
|
gptkbp:regulates
|
gptkb:NF-kappaB_signaling_pathway
cell proliferation
inflammatory response
apoptosis pathway
|
|
gptkbp:transmembraneDomains
|
true
|
|
gptkbp:UniProtID
|
gptkb:P20333
|
|
gptkbp:bfsParent
|
gptkb:P05362
gptkb:mouse_TNF
gptkb:rat_TNF
gptkb:TNFR2
gptkb:TNFRSF
gptkb:TNFRSF16
gptkb:lymphotoxin_alpha
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TNFRSF1B
|