|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:BSF2
gptkb:IFNB2
gptkb:IL-6
HSF
|
|
gptkbp:associatedWith
|
gptkb:COVID-19
gptkb:Castleman_disease
gptkb:systemic_lupus_erythematosus
rheumatoid arthritis
|
|
gptkbp:clinical_use
|
target of sarilumab
target of tocilizumab
|
|
gptkbp:discoveredBy
|
gptkb:Tadamitsu_Kishimoto
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000136244
3569
|
|
gptkbp:expressedIn
|
liver
endothelial cells
fibroblasts
immune cells
|
|
gptkbp:function
|
gptkb:immune_response
cytokine activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GO_term
|
gptkb:GO:0005125
GO:0006954
GO:0006955
|
|
gptkbp:HGNC_ID
|
6018
|
|
gptkbp:length
|
6 exons
212 amino acids
|
|
gptkbp:locatedOnChromosome
|
7
|
|
gptkbp:location
|
7p15.3
|
|
gptkbp:molecularWeight
|
23.7 kDa
|
|
gptkbp:name
|
gptkb:interleukin_6
|
|
gptkbp:OMIM
|
147620
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_Il6
gptkb:rat_Il6
|
|
gptkbp:pathway
|
gptkb:JAK-STAT_signaling_pathway
gptkb:MAPK_signaling_pathway
gptkb:Cytokine-cytokine_receptor_interaction
|
|
gptkbp:product
|
gptkb:interleukin-6
|
|
gptkbp:recipient
|
gptkb:gp130
gptkb:IL6R
|
|
gptkbp:regulates
|
induced by IL1
induced by LPS
induced by TNF
|
|
gptkbp:subcellularLocation
|
secreted
|
|
gptkbp:symbol
|
gptkb:IL6
|
|
gptkbp:UniProtID
|
gptkb:P05231
|
|
gptkbp:bfsParent
|
gptkb:P04049
gptkb:P21136
|
|
gptkbp:bfsLayer
|
7
|
|
http://www.w3.org/2000/01/rdf-schema#label
|
hsa:3630
|