|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:associatedWith
|
gptkb:COVID-19
gptkb:systemic_lupus_erythematosus
gptkb:Castleman's_disease
multiple myeloma
sepsis
rheumatoid arthritis
inflammatory bowel disease
|
|
gptkbp:discoveredBy
|
gptkb:Tadamitsu_Kishimoto
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:encodedBy
|
gptkb:IL6_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000136244
3569
|
|
gptkbp:fullName
|
gptkb:Interleukin-6
|
|
gptkbp:function
|
inflammatory response
immune response regulation
cytokine activity
B cell maturation
acute phase response
|
|
gptkbp:gene
|
gptkb:IL6
|
|
gptkbp:HGNC_ID
|
6018
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IL6
|
|
gptkbp:inducedBy
|
gptkb:trauma
infection
inflammation
|
|
gptkbp:length
|
212 amino acids
|
|
gptkbp:locatedOnChromosome
|
7p15.3
|
|
gptkbp:mainTerminal
|
gptkb:GO:0005125
GO:0006954
GO:0006955
GO:0006952
GO:0006953
|
|
gptkbp:molecularWeight
|
23.7 kDa
|
|
gptkbp:OMIM
|
147620
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_Il6
gptkb:rat_Il6
gptkb:zebrafish_il6
|
|
gptkbp:pathway
|
gptkb:JAK-STAT_signaling_pathway
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:PDB
|
gptkb:1ALU
|
|
gptkbp:recipient
|
gptkb:gp130
gptkb:IL6R
|
|
gptkbp:secretes
|
gptkb:T_cells
macrophages
endothelial cells
fibroblasts
|
|
gptkbp:structure
|
monomer
|
|
gptkbp:target
|
gptkb:tocilizumab
gptkb:sarilumab
gptkb:siltuximab
|
|
gptkbp:UniProtID
|
gptkb:P05231
|
|
gptkbp:bfsParent
|
gptkb:Il-62
gptkb:human_interleukin-6
|
|
gptkbp:bfsLayer
|
6
|