|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CD126
gptkb:IL-6R
IL-6RA
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cardiovascular_disease
asthma
autoimmune diseases
rheumatoid arthritis
inflammatory response
|
|
gptkbp:discoveredBy
|
Taga et al.
|
|
gptkbp:discoveredIn
|
1988
|
|
gptkbp:encodes
|
Interleukin-6 receptor subunit alpha
|
|
gptkbp:Entrez_Gene_ID
|
3570
ENSG00000160712
|
|
gptkbp:expressedIn
|
gptkb:hepatocytes
endothelial cells
immune cells
|
|
gptkbp:fullName
|
Interleukin-6 receptor
|
|
gptkbp:function
|
cytokine receptor activity
mediates IL-6 signaling
|
|
gptkbp:gene
|
gptkb:IL6R
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasPolymorphism
|
rs2228145
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
6019
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IL6R
|
|
gptkbp:interactsWith
|
gptkb:IL6
gptkb:gp130
|
|
gptkbp:length
|
468 amino acids
|
|
gptkbp:locatedOnChromosome
|
1
plus
1q21
|
|
gptkbp:location
|
gptkb:cell_membrane
soluble form in plasma
|
|
gptkbp:molecularWeight
|
51 kDa
|
|
gptkbp:OMIM
|
147880
|
|
gptkbp:orthologInMouse
|
Il6ra
|
|
gptkbp:pathway
|
gptkb:JAK-STAT_signaling_pathway
immune system
cytokine-cytokine receptor interaction
|
|
gptkbp:PDB
|
1N26
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:target
|
gptkb:tocilizumab
gptkb:sarilumab
|
|
gptkbp:UniProtID
|
P08887
|
|
gptkbp:bfsParent
|
gptkb:IL6
gptkb:interleukin-6_receptor
gptkb:P05231
gptkb:IL6ST
|
|
gptkbp:bfsLayer
|
7
|