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gptkbp:instanceOf
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UniProt accession number
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gptkbp:alternativeName
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gptkb:IFNB2
B-cell stimulatory factor 2
Hybridoma growth factor
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gptkbp:associatedWith
|
gptkb:COVID-19
gptkb:Castleman's_disease
Rheumatoid arthritis
Systemic juvenile idiopathic arthritis
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gptkbp:function
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Cytokine involved in inflammation and maturation of B cells
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gptkbp:gene
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gptkb:IL6
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gptkbp:GO
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GO:0005125 (cytokine activity)
GO:0006954 (inflammatory response)
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gptkbp:HGNC_ID
|
6018
|
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https://www.w3.org/2000/01/rdf-schema#label
|
P05231
|
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gptkbp:inducedBy
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gptkb:LPS
gptkb:TNF
IL1
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gptkbp:InterPro
|
IPR006053
|
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gptkbp:KEGGID
|
hsa:3569
|
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gptkbp:literatureReference
|
PMID: 3189234
PMID: 6332167
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gptkbp:locatedOnChromosome
|
7p15.3
Chromosome 7: 22,742,839-22,747,507 (GRCh38)
|
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gptkbp:molecularWeight
|
23,721 Da
|
|
gptkbp:OMIM
|
147620
|
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gptkbp:organism
|
gptkb:Homo_sapiens
|
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gptkbp:orthologIn
|
Chimpanzee IL6
Mouse Il6
Rat Il6
|
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gptkbp:pathway
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gptkb:JAK-STAT_signaling_pathway
gptkb:Cytokine-cytokine_receptor_interaction
|
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gptkbp:PDB
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gptkb:1ALU
1IL6
|
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gptkbp:postTranslationalModification
|
Disulfide bond
Glycosylation
|
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gptkbp:protein_name
|
gptkb:Interleukin-6
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gptkbp:proteinFamily
|
PF00889
|
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gptkbp:Reactome
|
R-HSA-6785807
|
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gptkbp:recipient
|
gptkb:gp130
gptkb:IL6R
|
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gptkbp:refersTo
|
gptkb:Interleukin-6
|
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gptkbp:RefSeq
|
NP_000591.1
|
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gptkbp:sequence
|
212
|
|
gptkbp:structure
|
Monomer
Can form homodimers
|
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gptkbp:subcellularLocation
|
Secreted
|
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gptkbp:tissue_specificity
|
Expressed in T-cells, macrophages, fibroblasts, endothelial cells
|
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gptkbp:UniGene
|
Hs.654497
|
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gptkbp:UniProtID
|
ENSP00000258743
|
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gptkbp:bfsParent
|
gptkb:interleukin-6
gptkb:human_interleukin-6
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gptkbp:bfsLayer
|
6
|