Castleman disease

GPTKB entity

Statements (35)
Predicate Object
gptkbp:instanceOf gptkb:disease
gptkbp:affects lymph nodes
gptkbp:alsoKnownAs angiofollicular lymph node hyperplasia
giant lymph node hyperplasia
gptkbp:associatedWith HIV infection
HHV-8 infection
gptkbp:complication leukemia
organ failure
gptkbp:diagnosedBy imaging studies
lymph node biopsy
gptkbp:field oncology
hematology
gptkbp:firstDescribed 1954
Benjamin Castleman
https://www.w3.org/2000/01/rdf-schema#label Castleman disease
gptkbp:ICD-10_code D47.Z2
gptkbp:prevalence rare
gptkbp:riskFactor immunosuppression
gptkbp:subspecies multicentric Castleman disease
unicentric Castleman disease
gptkbp:symptom fever
fatigue
weight loss
night sweats
enlarged lymph nodes
gptkbp:treatment chemotherapy
immunotherapy
corticosteroids
surgical excision (unicentric)
gptkbp:bfsParent gptkb:interleukin-6_receptor
gptkb:HGNC:5973
gptkb:IL-6_receptor
gptkb:IL6_gene
gptkb:siltuximab
gptkbp:bfsLayer 7