|
gptkbp:instanceOf
|
cytokine
|
|
gptkbp:alternativeName
|
gptkb:B_cell_stimulatory_factor_2
gptkb:hybridoma/plasmacytoma_growth_factor
gptkb:interferon_beta-2
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:systemic_lupus_erythematosus
sepsis
rheumatoid arthritis
chronic inflammation
COVID-19 severity
|
|
gptkbp:discoveredBy
|
gptkb:Tadamitsu_Kishimoto
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:encodedBy
|
gptkb:IL6_gene
|
|
gptkbp:Entrez_Gene_ID
|
3569
|
|
gptkbp:foundIn
|
humans
mice
other mammals
|
|
gptkbp:fullName
|
gptkb:Interleukin-6
|
|
gptkbp:function
|
immune response regulation
B cell maturation
acute phase response induction
inflammation mediation
T cell differentiation
|
|
gptkbp:gene
|
gptkb:IL6
|
|
gptkbp:halfLife
|
~1.5 hours
|
|
gptkbp:HGNC_ID
|
6018
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IL-6
|
|
gptkbp:involvedIn
|
gptkb:PI3K/AKT_signaling_pathway
gptkb:MAPK_signaling_pathway
gptkb:JAK/STAT_signaling_pathway
|
|
gptkbp:locatedOnChromosome
|
7p15.3
|
|
gptkbp:molecularWeight
|
21–28 kDa
|
|
gptkbp:OMIM
|
147620
|
|
gptkbp:producedBy
|
gptkb:T_cells
macrophages
endothelial cells
fibroblasts
monocytes
|
|
gptkbp:promotion
|
gptkb:cancer
gptkb:trauma
infection
burns
autoimmune disease
|
|
gptkbp:recipient
|
gptkb:gp130
IL-6 receptor (IL-6R)
|
|
gptkbp:RefSeq
|
gptkb:NM_000600
|
|
gptkbp:structure
|
four-helix bundle
|
|
gptkbp:target
|
gptkb:tocilizumab
gptkb:sarilumab
gptkb:siltuximab
|
|
gptkbp:UniProtID
|
gptkb:P05231
|
|
gptkbp:bfsParent
|
gptkb:interleukin-6
|
|
gptkbp:bfsLayer
|
6
|