|
gptkbp:instanceOf
|
cytokine
|
|
gptkbp:abbreviation
|
gptkb:IL-6
|
|
gptkbp:associatedWith
|
gptkb:COVID-19
gptkb:cancer
gptkb:systemic_lupus_erythematosus
sepsis
rheumatoid arthritis
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:encodedBy
|
gptkb:IL6_gene
|
|
gptkbp:Entrez_Gene_ID
|
3569
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
liver
adipose tissue
immune cells
|
|
gptkbp:function
|
immune response regulation
B cell maturation
acute phase response induction
inflammation mediation
|
|
gptkbp:halfLife
|
~1 hour
|
|
gptkbp:HGNC_ID
|
6018
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
interleukin 6
|
|
gptkbp:inducedBy
|
gptkb:fibrinogen
gptkb:C-reactive_protein
serum amyloid A
|
|
gptkbp:inhibitedBy
|
gptkb:IL-1
gptkb:TNF-alpha
|
|
gptkbp:locatedOnChromosome
|
7p15.3
|
|
gptkbp:molecularWeight
|
21 kDa
|
|
gptkbp:OMIM
|
147620
|
|
gptkbp:PDB
|
gptkb:1ALU
|
|
gptkbp:producedBy
|
gptkb:T_cells
macrophages
endothelial cells
fibroblasts
|
|
gptkbp:promotion
|
gptkb:IL-1
gptkb:TNF-alpha
gptkb:trauma
gptkb:hepatocytes
infection
exercise
|
|
gptkbp:recipient
|
gptkb:gp130
gptkb:IL-6_receptor
|
|
gptkbp:RefSeq
|
gptkb:NM_000600
|
|
gptkbp:structure
|
four-helix bundle
|
|
gptkbp:target
|
gptkb:tocilizumab
gptkb:sarilumab
gptkb:siltuximab
|
|
gptkbp:UniProtID
|
gptkb:P05231
|
|
gptkbp:bfsParent
|
gptkb:HGNC:5973
gptkb:HGNC:6348
gptkb:IL6_gene
|
|
gptkbp:bfsLayer
|
7
|