Cell division protein kinase 4

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alsoKnownAs	gptkb:CDK4
gptkbp:associatedWith	gptkb:cancer gptkb:glioblastoma melanoma
gptkbp:biologicalProcess	serine/threonine protein kinase activity
gptkbp:encodedBy	gptkb:CDK4_gene
gptkbp:Entrez_Gene_ID	1019
gptkbp:enzymeCommissionNumber	EC 2.7.11.22
gptkbp:function	regulation of cell cycle G1/S transition of mitotic cell cycle
gptkbp:GO_term	gptkb:GO:0004674 GO:0005515 GO:0005634 GO:0005524 GO:0000082 GO:0004693
https://www.w3.org/2000/01/rdf-schema#label	Cell division protein kinase 4
gptkbp:inhibitedBy	gptkb:p15INK4b gptkb:p16INK4a gptkb:p18INK4c gptkb:p19INK4d
gptkbp:interactsWith	gptkb:cyclin_D1 gptkb:cyclin_D2 gptkb:cyclin_D3
gptkbp:length	303 amino acids
gptkbp:locatedOnChromosome	12q14
gptkbp:molecularWeight	34 kDa
gptkbp:mutationAssociatedWith	gptkb:familial_melanoma cancer predisposition
gptkbp:OMIM	123829
gptkbp:organism	gptkb:Homo_sapiens
gptkbp:orthologIn	gptkb:mouse_Cdk4 gptkb:rat_Cdk4 gptkb:zebrafish_cdk4
gptkbp:PDB	gptkb:2W96
gptkbp:phosphorylates	gptkb:retinoblastoma_protein_(RB1)
gptkbp:postTranslationalModification	phosphorylation ubiquitination
gptkbp:regulates	activated by cyclin D binding inhibited by INK4 family proteins
gptkbp:subcellularLocation	gptkb:nucleus gptkb:cytoplasm
gptkbp:target	gptkb:palbociclib gptkb:ribociclib gptkb:abemaciclib CDK4/6 inhibitors
gptkbp:UniProtID	P11802
gptkbp:bfsParent	gptkb:CDK4
gptkbp:bfsLayer	7