|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CYP2A
gptkb:P450C2A
|
|
gptkbp:associatedWith
|
gptkb:CYP2A13
gptkb:CYP2A7
drug metabolism
nicotine dependence
|
|
gptkbp:encodes
|
gptkb:cytochrome_P450_2A6
|
|
gptkbp:Entrez_Gene_ID
|
1548
|
|
gptkbp:enzymeCommissionNumber
|
gptkb:EC_1.14.14.6
|
|
gptkbp:expressedIn
|
gptkb:cancer
liver
|
|
gptkbp:function
|
coumarin 7-hydroxylation
metabolism of xenobiotics
nicotine metabolism
|
|
gptkbp:hasPolymorphism
|
gptkb:CYP2A6*2_(inactive_variant)
gptkb:CYP2A6*4_(gene_deletion)
|
|
gptkbp:HGNC_ID
|
2597
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CYP2A6
|
|
gptkbp:inhibitedBy
|
gptkb:methoxsalen
gptkb:pilocarpine
gptkb:tranylcypromine
|
|
gptkbp:length
|
494 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_19
19q13.2
|
|
gptkbp:memberOf
|
gptkb:cytochrome_P450_superfamily
|
|
gptkbp:molecularWeight
|
56 kDa
|
|
gptkbp:mutationAssociatedWith
|
altered drug response
altered nicotine metabolism
|
|
gptkbp:OMIM
|
601040
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Cyp2a5
|
|
gptkbp:PDB
|
gptkb:1Z10
gptkb:2FDY
|
|
gptkbp:proteinFamily
|
gptkb:CYP2A
|
|
gptkbp:regulates
|
induced by phenobarbital
induced by rifampicin
inhibited by grapefruit juice
|
|
gptkbp:significance
|
pharmacogenomics
smoking cessation therapy
|
|
gptkbp:structure
|
gptkb:heme-thiolate_monooxygenase
|
|
gptkbp:substrate
|
gptkb:aflatoxin_B1
gptkb:tegafur
nicotine
coumarin
|
|
gptkbp:UniProtID
|
P11509
|
|
gptkbp:bfsParent
|
gptkb:CYP2_family
gptkb:CYP_family
|
|
gptkbp:bfsLayer
|
5
|