ABCC2

GPTKB entity

Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:gene
gptkbp:alsoKnownAs gptkb:MRP2
cMOAT
gptkbp:associatedWith gptkb:Dubin-Johnson_syndrome
gptkbp:encodes Multidrug resistance-associated protein 2
gptkbp:Entrez_Gene_ID 1244
ENSG00000105423
gptkbp:expressedIn gptkb:kidney
liver
intestine
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:fullName ATP binding cassette subfamily C member 2
gptkbp:function transports organic anions and drugs across cellular membranes
gptkbp:gene gptkb:ABCC2
gptkbp:geneType protein-coding
gptkbp:hasPolymorphism rs2273697
rs3740066
rs717620
gptkbp:HGNC_ID gptkb:HGNC:54
https://www.w3.org/2000/01/rdf-schema#label ABCC2
gptkbp:involvedIn detoxification
multidrug resistance
xenobiotic transport
gptkbp:length 1545 amino acids
gptkbp:locatedOnChromosome gptkb:chromosome_10
10q24
gptkbp:memberOf gptkb:ATP-binding_cassette_(ABC)_transporter_family
gptkbp:mutationAssociatedWith can cause impaired drug excretion
gptkbp:OMIM 601107
gptkbp:orthologInMouse Abcc2
gptkbp:product gptkb:cell_membrane
gptkbp:proteinSymbol gptkb:MRP2
gptkbp:publicTransit ABC transporter
gptkbp:regulates biliary excretion
gptkbp:relatedTo pharmacogenomics
bile secretion
drug metabolism
chemotherapy resistance
liver function
gptkbp:subfamily gptkb:subfamily_C_(CFTR/MRP)_of_ABC_transporters
gptkbp:transportation antibiotics
antiviral drugs
anticancer drugs
organic anions
bilirubin glucuronides
gptkbp:UniProtID O15438
gptkbp:bfsParent gptkb:Canalicular_multispecific_organic_anion_transporter
gptkb:constitutive_androstane_receptor
gptkbp:bfsLayer 7