|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:MDR1
gptkb:P-glycoprotein
|
|
gptkbp:associatedWith
|
chemotherapy resistance
|
|
gptkbp:discoveredBy
|
gptkb:Victor_Ling
|
|
gptkbp:discoveredIn
|
1976
|
|
gptkbp:encodes
|
gptkb:P-glycoprotein
|
|
gptkbp:Entrez_Gene_ID
|
5243
ENSG00000085563
|
|
gptkbp:expressedIn
|
gptkb:kidney
gptkb:blood-brain_barrier
liver
intestine
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
multidrug resistance
drug efflux transporter
|
|
gptkbp:geneLocationEnd
|
87,206,871
|
|
gptkbp:geneLocationReferenceGenome
|
gptkb:GRCh38
|
|
gptkbp:geneLocationStart
|
87,119,140
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:40
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ABCB1
|
|
gptkbp:inhibitedBy
|
gptkb:tariquidar
gptkb:verapamil
quinidine
cyclosporine A
elacridar
valspodar
|
|
gptkbp:involvedIn
|
pharmacokinetics
xenobiotic transport
|
|
gptkbp:length
|
1280 amino acids
|
|
gptkbp:locatedOnChromosome
|
7q21.12
|
|
gptkbp:memberOf
|
gptkb:ATP-binding_cassette_transporter_family
|
|
gptkbp:mutationAssociatedWith
|
drug resistance
altered drug absorption
|
|
gptkbp:OMIM
|
171050
|
|
gptkbp:orthologInMouse
|
Abcb1a
Abcb1b
|
|
gptkbp:product
|
transmembrane protein
|
|
gptkbp:regulates
|
bioavailability of drugs
blood-brain barrier permeability
|
|
gptkbp:structure
|
two homologous halves, each with six transmembrane domains and an ATP-binding site
|
|
gptkbp:substrate
|
gptkb:cyclosporine
gptkb:daunorubicin
gptkb:doxorubicin
gptkb:verapamil
gptkb:loperamide
gptkb:vincristine
gptkb:digoxin
quinidine
antineoplastic agent
paclitaxel
|
|
gptkbp:UniProtID
|
P08183
|
|
gptkbp:bfsParent
|
gptkb:MDR1
gptkb:MDR1_gene
gptkb:constitutive_androstane_receptor
gptkb:pregnane_X_receptor
|
|
gptkbp:bfsLayer
|
7
|