|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:BCRP
breast cancer resistance protein
|
|
gptkbp:associatedWith
|
drug resistance in cancer
pharmacokinetics of drugs
|
|
gptkbp:discoveredBy
|
Sarkadi et al.
|
|
gptkbp:discoveredIn
|
1998
|
|
gptkbp:encodes
|
ABCG2 protein
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000118777
9429
|
|
gptkbp:expressedIn
|
gptkb:placenta
gptkb:blood-brain_barrier
liver
stem cells
intestine
|
|
gptkbp:formsHomodimer
|
yes
|
|
gptkbp:fullName
|
ATP-binding cassette sub-family G member 2
|
|
gptkbp:function
|
gptkb:multidrug_resistance_protein
transmembrane transporter
exports xenobiotics and drugs from cells
|
|
gptkbp:HGNC_ID
|
HGNC:74
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ABCG2
|
|
gptkbp:inhibitedBy
|
gptkb:novobiocin
elacridar
Ko143
fumitremorgin C
|
|
gptkbp:involvedIn
|
uric acid transport
|
|
gptkbp:locatedOnChromosome
|
4q22.1
|
|
gptkbp:memberOf
|
gptkb:ATP-binding_cassette_transporter_family
G subfamily
|
|
gptkbp:mutationAssociatedWith
|
gout
hyperuricemia
drug resistance in chemotherapy
|
|
gptkbp:OMIM
|
603756
|
|
gptkbp:orthologInMouse
|
Abcg2
|
|
gptkbp:PDB
|
6FFC
6HCO
6VXI
|
|
gptkbp:regulates
|
upregulated by hypoxia
regulated by estrogen
regulated by nuclear receptors
|
|
gptkbp:structure
|
half-transporter
|
|
gptkbp:substrate
|
gptkb:methotrexate
gptkb:mitoxantrone
gptkb:topotecan
gptkb:sulfasalazine
antiviral drugs
estrone sulfate
uric acid
|
|
gptkbp:UniProtID
|
Q9UNQ0
|
|
gptkbp:bfsParent
|
gptkb:constitutive_androstane_receptor
|
|
gptkbp:bfsLayer
|
7
|