|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:ABCB1
gptkb:P-glycoprotein
|
|
gptkbp:discoveredBy
|
gptkb:Victor_Ling
|
|
gptkbp:discoveredIn
|
1976
|
|
gptkbp:encodes
|
gptkb:P-glycoprotein
|
|
gptkbp:Entrez_Gene_ID
|
5243
ENSG00000085563
|
|
gptkbp:expressedIn
|
gptkb:kidney
gptkb:blood-brain_barrier
liver
intestine
|
|
gptkbp:function
|
drug efflux transporter
|
|
gptkbp:HGNC_ID
|
HGNC:40
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MDR1
|
|
gptkbp:inhibitedBy
|
gptkb:tariquidar
gptkb:verapamil
cyclosporin A
|
|
gptkbp:involvedIn
|
multidrug resistance
|
|
gptkbp:length
|
1280 amino acids
|
|
gptkbp:locatedOnChromosome
|
7q21.12
|
|
gptkbp:memberOf
|
gptkb:ATP-binding_cassette_transporter_family
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
drug resistance
inflammatory bowel disease
|
|
gptkbp:OMIM
|
171050
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
Mus musculus (Abcb1a, Abcb1b)
|
|
gptkbp:product
|
transmembrane protein
|
|
gptkbp:regulates
|
gptkb:constitutive_androstane_receptor
gptkb:pregnane_X_receptor
nuclear receptors
|
|
gptkbp:role
|
pharmacokinetics
biliary drug excretion
blood-brain barrier permeability
intestinal drug absorption
renal drug excretion
|
|
gptkbp:significance
|
affects drug bioavailability
affects drug resistance in cancer
affects drug toxicity
|
|
gptkbp:structure
|
two homologous halves, each with six transmembrane domains
|
|
gptkbp:substrate
|
antibiotics
antiviral drugs
anticancer drugs
immunosuppressants
|
|
gptkbp:transportation
|
drugs
lipids
xenobiotics
|
|
gptkbp:UniProtID
|
P08183
|
|
gptkbp:bfsParent
|
gptkb:pfmdr1
|
|
gptkbp:bfsLayer
|
6
|