|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:S-mephenytoin_4-hydroxylase
gptkb:cytochrome_P450_family_2_subfamily_C_member_19
P450C2C
|
|
gptkbp:associatedWith
|
pharmacogenomics
adverse drug reactions
poor metabolizer phenotype
ultrarapid metabolizer phenotype
|
|
gptkbp:discoveredBy
|
U.S. researchers
|
|
gptkbp:encodes
|
gptkb:cytochrome_P450_2C19
|
|
gptkbp:Entrez_Gene_ID
|
1557
|
|
gptkbp:enzymeCommissionNumber
|
gptkb:EC_1.14.13.13
|
|
gptkbp:expressedIn
|
gptkb:small_intestine
liver
|
|
gptkbp:firstDescribed
|
1990s
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasClinicalTest
|
pharmacogenetic testing
|
|
gptkbp:hasPolymorphism
|
gptkb:CYP2C19*17
gptkb:CYP2C19*2
gptkb:CYP2C19*3
drug response
enzyme activity
|
|
gptkbp:HGNC_ID
|
2621
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CYP2C19
|
|
gptkbp:influenced
|
antidepressant metabolism
antiepileptic drug metabolism
antiplatelet therapy efficacy
proton pump inhibitor metabolism
|
|
gptkbp:involvedIn
|
drug metabolism
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_10
10q23.33
|
|
gptkbp:memberOf
|
gptkb:cytochrome_P450_superfamily
|
|
gptkbp:metabolism
|
gptkb:omeprazole
gptkb:clopidogrel
gptkb:diazepam
gptkb:mephenytoin
gptkb:proguanil
|
|
gptkbp:OMIM
|
124020
|
|
gptkbp:orthologInMouse
|
gptkb:Cyp2c11
gptkb:Cyp2c29
|
|
gptkbp:regulates
|
drug clearance
|
|
gptkbp:relatedTo
|
gptkb:CYP2C8
gptkb:CYP2C9
gptkb:CYP2C18
|
|
gptkbp:significance
|
personalized medicine
dose adjustment
|
|
gptkbp:UniProtID
|
gptkb:P33261
|
|
gptkbp:bfsParent
|
gptkb:rifampicin
gptkb:CYP2_family
gptkb:CYP_family
|
|
gptkbp:bfsLayer
|
5
|