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gptkbp:instanceOf
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gptkb:protein
gptkb:gene
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gptkbp:alternativeName
|
CYP2B6 protein
P450 2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
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gptkbp:associatedWith
|
pharmacogenomics
adverse drug reactions
drug response variability
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gptkbp:discoveredBy
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gptkb:F._Peter_Guengerich
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gptkbp:discoveredIn
|
1989
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gptkbp:encodes
|
cytochrome P450 2B6
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gptkbp:Entrez_Gene_ID
|
1555
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gptkbp:enzymeCommissionNumber
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gptkb:EC_1.14.14.1
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gptkbp:expressedIn
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gptkb:kidney
brain
liver
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gptkbp:function
|
drug metabolism
xenobiotic metabolism
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gptkbp:geneType
|
protein-coding
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gptkbp:hasPolymorphism
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CYP2B6*4
CYP2B6*5
CYP2B6*6
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gptkbp:hasTranscriptVariant
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CYP2B6-001
CYP2B6-002
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gptkbp:HGNC_ID
|
HGNC:2594
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|
https://www.w3.org/2000/01/rdf-schema#label
|
CYP2B6
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gptkbp:inducedBy
|
gptkb:rifampicin
gptkb:phenytoin
gptkb:carbamazepine
phenobarbital
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gptkbp:inhibitedBy
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gptkb:sertraline
gptkb:clopidogrel
gptkb:ticlopidine
thioTEPA
|
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gptkbp:length
|
491 amino acids
|
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gptkbp:locatedIn
|
gptkb:chromosome_19q13.2
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gptkbp:memberOf
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gptkb:cytochrome_P450_superfamily
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gptkbp:metabolism
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gptkb:cyclophosphamide
gptkb:methadone
gptkb:efavirenz
gptkb:ketamine
gptkb:bupropion
gptkb:propofol
gptkb:selegiline
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gptkbp:molecularWeight
|
56 kDa
|
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gptkbp:OMIM
|
123930
|
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gptkbp:orthologIn
|
gptkb:mouse
right
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gptkbp:regulates
|
gptkb:rifampicin
phenobarbital
CAR (constitutive androstane receptor)
PXR (pregnane X receptor)
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gptkbp:UniProtID
|
P20813
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gptkbp:bfsParent
|
gptkb:CYP2_family
gptkb:CYP_family
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gptkbp:bfsLayer
|
5
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