|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CYP2C9v
gptkb:P450C2C9
gptkb:cytochrome_P450,_family_2,_subfamily_C,_polypeptide_9
|
|
gptkbp:associatedWith
|
pharmacogenomics
adverse drug reactions
warfarin sensitivity
|
|
gptkbp:discoveredBy
|
gptkb:F._Peter_Guengerich
|
|
gptkbp:encodes
|
gptkb:cytochrome_P450_2C9
|
|
gptkbp:Entrez_Gene_ID
|
1559
|
|
gptkbp:enzymeCommissionNumber
|
gptkb:EC_1.14.13.35
|
|
gptkbp:expressedIn
|
gptkb:small_intestine
liver
|
|
gptkbp:function
|
drug metabolism
oxidation of xenobiotics
metabolism of arachidonic acid
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasPolymorphism
|
gptkb:CYP2C9*11
gptkb:CYP2C9*2
gptkb:CYP2C9*3
gptkb:CYP2C9*5
gptkb:CYP2C9*6
gptkb:CYP2C9*8
|
|
gptkbp:HGNC_ID
|
2623
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CYP2C9
|
|
gptkbp:inducedBy
|
gptkb:rifampicin
gptkb:carbamazepine
phenobarbital
|
|
gptkbp:inhibitedBy
|
gptkb:sulfaphenazole
gptkb:fluconazole
amiodarone
|
|
gptkbp:length
|
490 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_10
10q23.33
|
|
gptkbp:memberOf
|
gptkb:cytochrome_P450_superfamily
|
|
gptkbp:metabolism
|
gptkb:diclofenac
gptkb:phenytoin
gptkb:warfarin
gptkb:S-warfarin
gptkb:glipizide
gptkb:glyburide
gptkb:tolbutamide
gptkb:NSAIDs
gptkb:losartan
gptkb:celecoxib
gptkb:fluvastatin
|
|
gptkbp:molecularWeight
|
55 kDa
|
|
gptkbp:OMIM
|
601130
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Cyp2c11
gptkb:Cyp2c29
|
|
gptkbp:UniProtID
|
P11712
|
|
gptkbp:bfsParent
|
gptkb:protein
|
|
gptkbp:bfsLayer
|
4
|