Statements (14)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
small molecule
|
| gptkbp:alternativeName |
spiro-oxindole MDM2 inhibitor
|
| gptkbp:chemicalClass |
spiro-oxindole derivative
|
| gptkbp:developedBy |
gptkb:cancer
Ascenta Therapeutics |
| https://www.w3.org/2000/01/rdf-schema#label |
MI-219
|
| gptkbp:inducedBy |
apoptosis in cancer cells
|
| gptkbp:mechanismOfAction |
MDM2-p53 interaction inhibitor
|
| gptkbp:restored |
p53 tumor suppressor function
|
| gptkbp:studiedIn |
preclinical models
|
| gptkbp:target |
gptkb:MDM2
|
| gptkbp:bfsParent |
gptkb:Mdm2
gptkb:cellular_tumor_antigen_p53 |
| gptkbp:bfsLayer |
7
|