Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
small molecule
MDM2 inhibitor |
| gptkbp:CASNumber |
548472-68-0
|
| gptkbp:category |
experimental cancer drug
|
| gptkbp:chemicalFormula |
C30H30Cl2N4O4
|
| gptkbp:developedBy |
gptkb:Hoffmann-La_Roche
|
| gptkbp:discoveredBy |
2004
|
| gptkbp:effect |
induces apoptosis in cancer cells
activates p53 pathway stabilizes p53 protein |
| https://www.w3.org/2000/01/rdf-schema#label |
nutlin-3
|
| gptkbp:IUPACName |
4-[(4,5-dihydro-4,4-diphenyl-1H-imidazol-2-yl)amino]-2-(4-morpholinyl)-5,5-dimethyl-2,5-dihydro-1H-imidazol-1-one
|
| gptkbp:mechanismOfAction |
inhibits MDM2-p53 interaction
|
| gptkbp:molecularWeight |
581.49 g/mol
|
| gptkbp:PubChem_CID |
gptkb:CHEMBL1213106
9932229 |
| gptkbp:routeOfAdministration |
in vitro
in vivo (animal models) |
| gptkbp:synonym |
gptkb:Nutlin-3a
gptkb:Nutlin-3b |
| gptkbp:target |
gptkb:MDM2
|
| gptkbp:tested_in |
preclinical studies
|
| gptkbp:UNII |
6Z5B6HVF6O
|
| gptkbp:used_in |
cancer research
leukemia research solid tumor research |
| gptkbp:bfsParent |
gptkb:MDM2
|
| gptkbp:bfsLayer |
6
|