|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:BCC7
gptkb:LFS1
P53
|
|
gptkbp:approvedBy
|
gptkb:tumor_protein_p53
|
|
gptkbp:approvedSymbol
|
gptkb:TP53
|
|
gptkbp:associatedWith
|
gptkb:Li-Fraumeni_syndrome
various cancers
|
|
gptkbp:discoveredIn
|
1979
|
|
gptkbp:Entrez_Gene_ID
|
7157
ENSG00000141510
|
|
gptkbp:essentialGene
|
true
|
|
gptkbp:function
|
tumor suppressor
transcription factor
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GO_term
|
GO:0003677 (DNA binding)
GO:0008285 (negative regulation of cell proliferation)
GO:0003700 (transcription factor activity)
GO:0006977 (DNA damage response)
|
|
gptkbp:hasPseudogene
|
yes
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:11762
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HGNC:11762
|
|
gptkbp:isOncogene
|
false
|
|
gptkbp:isTumorSuppressor
|
true
|
|
gptkbp:length
|
393 amino acids
|
|
gptkbp:locatedOnChromosome
|
17
17p13.1
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locusType
|
gene with protein product
|
|
gptkbp:molecularWeight
|
43.7 kDa
|
|
gptkbp:OMIM
|
191170
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Trp53
|
|
gptkbp:pathway
|
apoptosis
DNA repair
senescence
cell cycle arrest
p53 signaling pathway
|
|
gptkbp:previousName
|
gptkb:antigen_NY-CO-13
gptkb:phosphoprotein_p53
gptkb:tumor_suppressor_p53
|
|
gptkbp:previousSymbols
|
gptkb:BCC7
gptkb:LFS1
P53
|
|
gptkbp:product
|
gptkb:cellular_tumor_antigen_p53
|
|
gptkbp:proteinFamily
|
gptkb:p53_family
|
|
gptkbp:RefSeq
|
gptkb:NP_000537
gptkb:NM_000546
|
|
gptkbp:species
|
gptkb:human
|
|
gptkbp:symbol
|
gptkb:TP53
|
|
gptkbp:UniProtID
|
P04637
|
|
gptkbp:bfsParent
|
gptkb:TRF
|
|
gptkbp:bfsLayer
|
6
|