|
gptkbp:instanceOf
|
biological pathway
|
|
gptkbp:activatedBy
|
gptkb:PLCγ_pathway
gptkb:Src_family_kinases
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:associatedWith
|
gptkb:cancer
wound healing
age-related macular degeneration
diabetic retinopathy
tumor growth
|
|
gptkbp:hasComponent
|
gptkb:NRP1
gptkb:NRP2
gptkb:VEGFA
gptkb:VEGFR1
gptkb:VEGFR2
gptkb:VEGFR3
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
VEGF signaling pathway
|
|
gptkbp:inhibitedBy
|
gptkb:bevacizumab
gptkb:aflibercept
gptkb:ranibizumab
gptkb:sorafenib
gptkb:sunitinib
|
|
gptkbp:involves
|
gptkb:VEGF_receptor
gptkb:vascular_endothelial_growth_factor
|
|
gptkbp:is_a_target_for
|
anti-angiogenic therapy
|
|
gptkbp:is_encoded_in
|
KEGG pathway hsa04370
Reactome pathway R-HSA-194138
|
|
gptkbp:modulatedBy
|
gptkb:integrins
extracellular matrix
proteases
|
|
gptkbp:partOf
|
signal transduction
cell communication
|
|
gptkbp:regulates
|
gptkb:HIF-1α
gptkb:hypoxia
angiogenesis
cytokines
growth factors
endothelial cell proliferation
vascular permeability
endothelial cell migration
endothelial cell survival
|
|
gptkbp:requires
|
embryonic development
blood vessel formation
|
|
gptkbp:studiedBy
|
oncology
ophthalmology
cardiovascular research
|
|
gptkbp:target
|
anti-VEGF drugs
|
|
gptkbp:bfsParent
|
gptkb:F-BVFA
|
|
gptkbp:bfsLayer
|
5
|