|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
produces multiple isoforms
|
|
gptkbp:associatedWith
|
gptkb:cancer
psoriasis
age-related macular degeneration
diabetic retinopathy
rheumatoid arthritis
|
|
gptkbp:biologicalProcess
|
wound healing
angiogenesis
endothelial cell proliferation
growth factor activity
|
|
gptkbp:discoveredBy
|
gptkb:Napoleone_Ferrara
|
|
gptkbp:discoveredIn
|
1989
|
|
gptkbp:encodedBy
|
gptkb:VEGFA_gene
|
|
gptkbp:expressedIn
|
endothelial cells
tumor cells
|
|
gptkbp:fullName
|
gptkb:Vascular_endothelial_growth_factor_A
|
|
gptkbp:function
|
increases vascular permeability
stimulates vasculogenesis and angiogenesis
|
|
gptkbp:gene
|
gptkb:VEGFA
|
|
gptkbp:GOID
|
gptkb:GO:0005178
|
|
gptkbp:HGNC_ID
|
HGNC:12680
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
F-BVFA
|
|
gptkbp:locatedOnChromosome
|
gptkb:6p21.1
|
|
gptkbp:medicalUse
|
target for anti-angiogenic therapy
|
|
gptkbp:molecularWeight
|
~27 kDa (monomer)
|
|
gptkbp:OMIM
|
192240
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Bos_taurus
gptkb:Gallus_gallus
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:pathway
|
gptkb:VEGF_signaling_pathway
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:PDB
|
1VPF
|
|
gptkbp:postTranslationalModification
|
disulfide bonds
glycosylation
|
|
gptkbp:recipient
|
gptkb:NRP1
gptkb:NRP2
gptkb:VEGFR1
gptkb:VEGFR2
|
|
gptkbp:regulates
|
regulated by HIF1A
upregulated by hypoxia
|
|
gptkbp:sequence
|
secreted protein
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:target
|
gptkb:bevacizumab
gptkb:aflibercept
gptkb:ranibizumab
|
|
gptkbp:UniProtID
|
P15692
|
|
gptkbp:bfsParent
|
gptkb:aircraft
|
|
gptkbp:bfsLayer
|
4
|