Statements (34)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:associatedWith |
autoimmune diseases
cancer metastasis |
| gptkbp:binds |
gptkb:fibronectin
gptkb:laminin collagen extracellular matrix proteins |
| gptkbp:component |
gptkb:cell_membrane
|
| gptkbp:composedOf |
alpha subunit
beta subunit |
| gptkbp:discoveredBy |
gptkb:Richard_O._Hynes
gptkb:Erick_Ruoslahti |
| gptkbp:discoveredIn |
1980s
|
| gptkbp:example |
gptkb:α5β1_integrin
gptkb:αIIbβ3_integrin gptkb:αvβ3_integrin |
| gptkbp:foundIn |
animals
|
| gptkbp:function |
signal transduction
cell adhesion |
| https://www.w3.org/2000/01/rdf-schema#label |
integrins
|
| gptkbp:involvedIn |
wound healing
cell migration immune response platelet aggregation |
| gptkbp:modulatedBy |
cell signaling pathways
|
| gptkbp:proteinFamily |
gptkb:ITGA
gptkb:ITGB |
| gptkbp:relatedTo |
cytoskeleton
focal adhesions |
| gptkbp:structure |
heterodimer
|
| gptkbp:target |
therapeutic drugs
|
| gptkbp:bfsParent |
gptkb:PTK2
gptkb:VEGF_signaling_pathway |
| gptkbp:bfsLayer |
6
|