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gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:KDR
gptkb:CD309
gptkb:Flk-1
|
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gptkbp:associatedWith
|
gptkb:age-related_macular_degeneration
gptkb:cancer
diabetic retinopathy
retinopathy of prematurity
pre-eclampsia
|
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gptkbp:discoveredBy
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gptkb:Napoleone_Ferrara
|
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gptkbp:discoveredIn
|
1992
|
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gptkbp:encodedBy
|
gptkb:KDR_gene
|
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gptkbp:Entrez_Gene_ID
|
3791
|
|
gptkbp:expressedIn
|
endothelial cells
|
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gptkbp:function
|
gptkb:receptor_tyrosine_kinase
mediates vascular endothelial growth factor signaling
|
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gptkbp:ligand
|
gptkb:VEGF-A
gptkb:VEGF-C
gptkb:VEGF-D
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_4q12
|
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gptkbp:location
|
gptkb:cell_membrane
|
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gptkbp:molecularWeight
|
approximately 200 kDa
|
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gptkbp:organism
|
gptkb:Homo_sapiens
|
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gptkbp:pathway
|
gptkb:VEGF_signaling_pathway
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:Ras_signaling_pathway
|
|
gptkbp:PDB
|
3V2A
|
|
gptkbp:phosphorylates
|
Y1175
Y1214
Y951
|
|
gptkbp:role
|
angiogenesis
tumor growth
endothelial cell proliferation
tumor metastasis
vasculogenesis
endothelial cell migration
|
|
gptkbp:structure
|
transmembrane domain
extracellular ligand-binding domain
intracellular tyrosine kinase domain
|
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gptkbp:target
|
gptkb:bevacizumab
gptkb:sorafenib
gptkb:cabozantinib
gptkb:vandetanib
gptkb:pazopanib
gptkb:regorafenib
gptkb:sunitinib
gptkb:lenvatinib
gptkb:axitinib
gptkb:ramucirumab
|
|
gptkbp:UniProtID
|
P35968
|
|
gptkbp:bfsParent
|
gptkb:SU5498
|
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gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
VEGFR2
|