|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
produces multiple isoforms
|
|
gptkbp:biologicalProcess
|
embryonic development
wound healing
angiogenesis
endothelial cell proliferation
vasculogenesis
|
|
gptkbp:discoveredBy
|
gptkb:Napoleone_Ferrara
|
|
gptkbp:discoveredIn
|
1989
|
|
gptkbp:encodedBy
|
gptkb:VEGFA_gene
|
|
gptkbp:Entrez_Gene_ID
|
7422
ENSG00000112715
|
|
gptkbp:fullName
|
gptkb:Vascular_Endothelial_Growth_Factor_A
|
|
gptkbp:function
|
increases vascular permeability
promotes endothelial cell growth
stimulates angiogenesis
|
|
gptkbp:gene
|
gptkb:VEGFA
|
|
gptkbp:hasIsoform
|
gptkb:VEGF121
gptkb:VEGF189
gptkb:VEGF206
gptkb:VEGF165
|
|
gptkbp:HGNC_ID
|
HGNC:12680
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
VEGF-A
|
|
gptkbp:inducedBy
|
gptkb:hypoxia
growth factors
oncogenes
|
|
gptkbp:inhibitedBy
|
tyrosine kinase inhibitors
anti-VEGF antibodies
|
|
gptkbp:locatedOnChromosome
|
gptkb:6p21.1
|
|
gptkbp:location
|
secreted
|
|
gptkbp:molecularWeight
|
~23 kDa (VEGF165 isoform)
|
|
gptkbp:OMIM
|
192240
|
|
gptkbp:organism
|
gptkb:human
|
|
gptkbp:orthologIn
|
gptkb:zebrafish_vegfaa
mouse Vegfa
rat Vegfa
|
|
gptkbp:pathway
|
gptkb:VEGF_signaling_pathway
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:PDB
|
1VPF
|
|
gptkbp:postTranslationalModification
|
glycosylation
disulfide bond formation
|
|
gptkbp:recipient
|
gptkb:NRP1
gptkb:VEGFR-1
gptkb:VEGFR-2
|
|
gptkbp:relatedTo
|
cancer progression
age-related macular degeneration
diabetic retinopathy
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:target
|
gptkb:bevacizumab
gptkb:aflibercept
gptkb:ranibizumab
|
|
gptkbp:UniProtID
|
P15692
|
|
gptkbp:bfsParent
|
gptkb:bevacizumab
gptkb:aflibercept
gptkb:VEGFA
gptkb:VEGFA_gene
gptkb:VEGFR1
gptkb:VEGFR2
gptkb:Vascular_endothelial_growth_factor_A
gptkb:Eylea
gptkb:vascular_endothelial_growth_factor_A
|
|
gptkbp:bfsLayer
|
6
|