|
gptkbp:instanceOf
|
gptkb:receptor_tyrosine_kinase
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:FLT1
gptkb:Fms-like_tyrosine_kinase_1
|
|
gptkbp:binds
|
gptkb:VEGF-A
gptkb:VEGF-B
gptkb:PlGF
|
|
gptkbp:cellularComponent
|
gptkb:endosome
gptkb:plasma_membrane
|
|
gptkbp:discoveredBy
|
Simons et al.
|
|
gptkbp:domain
|
tyrosine kinase domain
immunoglobulin-like domains
|
|
gptkbp:encodedBy
|
gptkb:FLT1_gene
|
|
gptkbp:expressedIn
|
macrophages
endothelial cells
monocytes
|
|
gptkbp:fullName
|
gptkb:Vascular_Endothelial_Growth_Factor_Receptor_1
|
|
gptkbp:function
|
regulation of angiogenesis
endothelial cell proliferation
vascular permeability
|
|
gptkbp:hasIsoform
|
gptkb:soluble_VEGFR1_(sFlt-1)
|
|
gptkbp:HGNC_ID
|
HGNC:3763
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
VEGFR1
|
|
gptkbp:involvedIn
|
gptkb:cancer
retinopathy
pre-eclampsia
|
|
gptkbp:locatedOn
|
gptkb:chromosome_13q12
|
|
gptkbp:molecularWeight
|
180 kDa
|
|
gptkbp:mutationAssociatedWith
|
vascular malformations
pre-eclampsia
|
|
gptkbp:OMIM
|
165070
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:PDB
|
3HNG
|
|
gptkbp:phosphorylates
|
Y1213
Y1333
|
|
gptkbp:regulates
|
inflammatory response
vascular development
|
|
gptkbp:relatedTo
|
gptkb:VEGFR2
gptkb:VEGFR3
|
|
gptkbp:structure
|
transmembrane domain
extracellular ligand-binding domain
intracellular tyrosine kinase domain
|
|
gptkbp:target
|
monoclonal antibodies
tyrosine kinase inhibitors
anti-angiogenic drugs
|
|
gptkbp:UniProtID
|
P17948
|
|
gptkbp:bfsParent
|
gptkb:F-BVFA
gptkb:Lenvima
|
|
gptkbp:bfsLayer
|
5
|