|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:VEGF
gptkb:MVCD1
gptkb:VPF
gptkb:Vascular_permeability_factor
|
|
gptkbp:alternativeSplicing
|
produces multiple isoforms
|
|
gptkbp:associatedWith
|
gptkb:cancer
age-related macular degeneration
diabetic retinopathy
pre-eclampsia
|
|
gptkbp:biologicalProcess
|
cell proliferation
cell migration
growth factor activity
blood vessel morphogenesis
|
|
gptkbp:clinicalTrialPhase
|
anti-VEGF therapy
|
|
gptkbp:discoveredBy
|
gptkb:Napoleone_Ferrara
|
|
gptkbp:discoveredIn
|
1989
|
|
gptkbp:encodes
|
gptkb:VEGF-A_protein
|
|
gptkbp:Entrez_Gene_ID
|
7422
ENSG00000112715
|
|
gptkbp:expressedIn
|
endothelial cells
tumor cells
|
|
gptkbp:expressionDecreasedBy
|
anti-VEGF drugs
|
|
gptkbp:expressionIncreasedBy
|
gptkb:hypoxia
|
|
gptkbp:fullName
|
gptkb:vascular_endothelial_growth_factor_A
|
|
gptkbp:function
|
increases vascular permeability
promotes endothelial cell growth
stimulates angiogenesis
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:12680
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
VEGFA
|
|
gptkbp:locatedOnChromosome
|
gptkb:6p21.1
|
|
gptkbp:mutationAssociatedWith
|
hereditary vascular diseases
|
|
gptkbp:OMIM
|
192240
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:pathway
|
gptkb:VEGF_signaling_pathway
angiogenesis pathway
|
|
gptkbp:product
|
gptkb:VEGF-A
|
|
gptkbp:recipient
|
gptkb:NRP1
gptkb:VEGFR1
gptkb:VEGFR2
|
|
gptkbp:regulates
|
regulated by HIF1A
upregulated by hypoxia
|
|
gptkbp:target
|
gptkb:bevacizumab
gptkb:aflibercept
gptkb:ranibizumab
|
|
gptkbp:UniProtID
|
P15692
|
|
gptkbp:bfsParent
|
gptkb:F-BVFA
|
|
gptkbp:bfsLayer
|
5
|