vascular endothelial growth factor A

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:abbreviation	gptkb:VEGF-A
gptkbp:alternativeSplicing	produces multiple isoforms
gptkbp:associatedWith	gptkb:cancer psoriasis age-related macular degeneration diabetic retinopathy rheumatoid arthritis
gptkbp:biologicalProcess	cell proliferation wound healing growth factor activity blood vessel morphogenesis
gptkbp:discoveredBy	gptkb:Napoleone_Ferrara
gptkbp:discoveredIn	1989
gptkbp:Entrez_Gene_ID	ENSG00000112715 GC06M043339
gptkbp:foundIn	gptkb:Mus_musculus gptkb:Homo_sapiens
gptkbp:function	increases vascular permeability promotes endothelial cell growth stimulates angiogenesis
gptkbp:gene	gptkb:VEGFA
gptkbp:HGNC_ID	HGNC:12680
https://www.w3.org/2000/01/rdf-schema#label	vascular endothelial growth factor A
gptkbp:locatedOnChromosome	gptkb:6p21.1
gptkbp:location	extracellular space secreted
gptkbp:member	gptkb:vascular_endothelial_growth_factor_family
gptkbp:OMIM	192240
gptkbp:pathway	gptkb:VEGF_signaling_pathway gptkb:MAPK_signaling_pathway gptkb:PI3K-Akt_signaling_pathway
gptkbp:postTranslationalModification	glycosylation disulfide bond formation
gptkbp:recipient	gptkb:NRP1 gptkb:NRP2 gptkb:VEGFR1 gptkb:VEGFR2
gptkbp:significance	implicated in age-related macular degeneration implicated in diabetic retinopathy target for anti-angiogenic cancer therapy
gptkbp:structure	homodimer
gptkbp:targetOfDrug	gptkb:bevacizumab gptkb:aflibercept gptkb:ranibizumab gptkb:pegaptanib
gptkbp:UniProtID	P15692
gptkbp:bfsParent	gptkb:Lucentis
gptkbp:bfsLayer	5