TrkB tyrosine kinase receptor

URI: https://gptkb.org/entity/TrkB_tyrosine_kinase_receptor
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:receptor_tyrosine_kinase
gptkb:protein
gptkbp:activatedBy ligand binding
gptkbp:alternativeSplicing gptkb:TrkB-FL
gptkb:TrkB-T1
gptkb:TrkB-T2
gptkbp:binds gptkb:brain-derived_neurotrophic_factor
gptkb:neurotrophin-3
gptkb:neurotrophin-4
gptkbp:discoveredBy gptkb:Yves-Alain_Barde
gptkbp:domain transmembrane domain
extracellular ligand-binding domain
intracellular tyrosine kinase domain
gptkbp:downstreamOf gptkb:PLCĪ³_pathway
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
gptkbp:encodedBy gptkb:NTRK2_gene
gptkbp:expressedIn gptkb:cancer
gptkb:skeletal_muscle
heart
retina
central nervous system
peripheral nervous system
gptkbp:foundIn gptkb:human
gptkb:mouse
right
gptkbp:function neurotrophin receptor
https://www.w3.org/2000/01/rdf-schema#label TrkB tyrosine kinase receptor
gptkbp:involvedIn gptkb:synaptic_plasticity
cell survival
learning
neuronal development
memory formation
gptkbp:locatedOnChromosome chromosome 9q21.33 (human)
gptkbp:memberOf gptkb:neurotrophic_tyrosine_kinase_receptor_family
gptkbp:mutationAssociatedWith gptkb:neuroblastoma
gptkb:cancer
gptkb:depression
gptkb:autism_spectrum_disorder
schizophrenia
gptkbp:otherName gptkb:NTRK2
tropomyosin receptor kinase B
gptkbp:phosphorylates tyrosine residues
gptkbp:relatedTo gptkb:TrkA
gptkb:TrkC
gptkbp:target monoclonal antibodies
small molecule inhibitors
antidepressant drugs
gptkbp:bfsParent gptkb:TrkB_receptor
gptkbp:bfsLayer 8