|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeIsoform
|
gptkb:TrkB-T1
gptkb:TrkB-T2
gptkb:TrkB-Shc
|
|
gptkbp:alternativeSplicing
|
gptkb:NTRK2_gene
|
|
gptkbp:binds
|
gptkb:BDNF
gptkb:NT-3
gptkb:NT-4
|
|
gptkbp:diseaseRelevance
|
gptkb:neuroblastoma
gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease
gptkb:glioblastoma
gptkb:Huntington's_disease
gptkb:autism_spectrum_disorder
gptkb:major_depressive_disorder
epilepsy
schizophrenia
stroke
|
|
gptkbp:domain
|
transmembrane domain
extracellular ligand-binding domain
intracellular tyrosine kinase domain
|
|
gptkbp:encodedBy
|
gptkb:NTRK2_gene
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:skeletal_muscle
brain
heart
retina
pancreas
peripheral nervous system
|
|
gptkbp:fullName
|
gptkb:Tropomyosin_receptor_kinase_B_full-length
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TrkB-FL
|
|
gptkbp:locale
|
gptkb:cell_membrane
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:depression
gptkb:autism_spectrum_disorder
neurological disorders
|
|
gptkbp:phosphorylates
|
autophosphorylation upon ligand binding
|
|
gptkbp:role
|
gptkb:synaptic_plasticity
neuronal differentiation
neuronal survival
neurodevelopment
neuroprotection
memory formation
|
|
gptkbp:signalTransductionPathway
|
gptkb:PLCĪ³_pathway
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:UniProtID
|
Q16620-1
|
|
gptkbp:bfsParent
|
gptkb:TrkB
|
|
gptkbp:bfsLayer
|
7
|