|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:BDNF/NT-3_growth_factors_receptor
gptkb:TRKB
gptkb:neurotrophic_tyrosine_kinase_receptor_type_2
|
|
gptkbp:alternativeSplicing
|
produces multiple transcript variants
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:synaptic_plasticity
neuronal survival
neurodevelopment
psychiatric disorders
|
|
gptkbp:discoveredBy
|
Lamballe et al.
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:encodes
|
gptkb:TrkB_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000148053
4915
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:skeletal_muscle
brain
heart
peripheral nervous system
|
|
gptkbp:function
|
encodes a receptor tyrosine kinase
involved in neurotrophin signaling
|
|
gptkbp:HGNC_ID
|
8032
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NTRK2 gene
|
|
gptkbp:interactsWith
|
gptkb:BDNF
gptkb:NT-3
gptkb:NT-4
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_9
gptkb:9q21.33
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:autism_spectrum_disorder
obesity
developmental delay
|
|
gptkbp:OMIM
|
600456
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Ntrk2
|
|
gptkbp:pathway
|
gptkb:PLCĪ³_pathway
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
|
|
gptkbp:product
|
gptkb:TrkB
|
|
gptkbp:proteinFamily
|
gptkb:neurotrophic_tyrosine_kinase_receptor_family
|
|
gptkbp:regulates
|
axon growth
neuronal differentiation
neuronal survival
memory formation
synaptic strength
|
|
gptkbp:target
|
cancer therapies
antidepressant drugs
|
|
gptkbp:UniProtID
|
gptkb:Q16620
|
|
gptkbp:bfsParent
|
gptkb:TrkB
|
|
gptkbp:bfsLayer
|
7
|