brain-derived neurotrophic factor

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:abbreviation	gptkb:BDNF
gptkbp:associatedWith	gptkb:Alzheimer's_disease gptkb:Parkinson's_disease gptkb:Huntington's_disease gptkb:major_depressive_disorder bipolar disorder epilepsy schizophrenia
gptkbp:discoveredBy	gptkb:Yves-Alain_Barde
gptkbp:discoveredIn	1982
gptkbp:encodedBy	gptkb:BDNF_gene
gptkbp:Entrez_Gene_ID	gptkb:ENSG00000176697 627
gptkbp:expressedIn	gptkb:spinal_cord gptkb:basal_forebrain gptkb:cerebellum gptkb:cortex hippocampus
gptkbp:foundIn	brain peripheral nervous system
gptkbp:function	encourages growth of new neurons and synapses supports survival of existing neurons
gptkbp:hasPolymorphism	gptkb:Val66Met
gptkbp:HGNC_ID	1033
https://www.w3.org/2000/01/rdf-schema#label	brain-derived neurotrophic factor
gptkbp:locatedOnChromosome	gptkb:chromosome_11p14.1
gptkbp:memberOf	neurotrophin family
gptkbp:molecularWeight	~27 kDa
gptkbp:OMIM	113505
gptkbp:orthologIn	gptkb:human gptkb:meat gptkb:mouse gptkb:zebrafish right
gptkbp:recipient	gptkb:p75NTR gptkb:TrkB
gptkbp:regulates	exercise increases BDNF levels stress decreases BDNF levels
gptkbp:relatedTo	gptkb:depression gptkb:synaptic_plasticity gptkb:long-term_potentiation memory learning neuroplasticity
gptkbp:structure	dimer
gptkbp:UniProtID	gptkb:P23560
gptkbp:Val66Met	affects activity-dependent secretion associated with memory impairment associated with psychiatric disorders
gptkbp:bfsParent	gptkb:nerve_growth_factor
gptkbp:bfsLayer	5