|
gptkbp:instanceOf
|
gptkb:protein
growth factor
|
|
gptkbp:associatedWith
|
gptkb:depression
schizophrenia
neurodegenerative diseases
peripheral neuropathy
|
|
gptkbp:binds
|
gptkb:p75NTR
gptkb:TrkB
gptkb:TrkC
|
|
gptkbp:discoveredBy
|
1990
|
|
gptkbp:Entrez_Gene_ID
|
GC12M103425
|
|
gptkbp:expressedIn
|
gptkb:peripheral_blood_leukocyte
gptkb:cancer
gptkb:skeletal_muscle
gptkb:kidney
gptkb:placenta
gptkb:prostate
gptkb:small_intestine
gptkb:testis
gptkb:thymus
brain
heart
liver
spleen
colon
pancreas
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:function
|
promotes survival and differentiation of neurons
|
|
gptkbp:gene
|
gptkb:NTF3
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
neurotrophin-3
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12q24
|
|
gptkbp:member
|
neurotrophin family
|
|
gptkbp:molecularWeight
|
13.6 kDa (mature form)
27 kDa (precursor)
|
|
gptkbp:OMIM
|
162645
|
|
gptkbp:relatedTo
|
gptkb:nerve_growth_factor
gptkb:brain-derived_neurotrophic_factor
gptkb:neurotrophin-4
|
|
gptkbp:role
|
gptkb:synaptic_plasticity
axon growth
dendrite growth
neuronal survival
development of peripheral nervous system
development of central nervous system
|
|
gptkbp:sequence
|
119 amino acids (mature form)
257 amino acids (precursor)
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:UniProtID
|
P20783
|
|
gptkbp:bfsParent
|
gptkb:p75NTR
|
|
gptkbp:bfsLayer
|
6
|