neurotrophic tyrosine kinase receptor family
GPTKB entity
Statements (26)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
NTRK family
|
| gptkbp:associatedWith |
gptkb:cancer
neuronal development |
| gptkbp:discoveredIn |
1990s
|
| gptkbp:domain |
extracellular ligand-binding domain
tyrosine kinase domain |
| gptkbp:encodedBy |
NTRK genes
|
| gptkbp:function |
signal transduction
receptor for neurotrophins |
| https://www.w3.org/2000/01/rdf-schema#label |
neurotrophic tyrosine kinase receptor family
|
| gptkbp:ligand |
gptkb:nerve_growth_factor
gptkb:brain-derived_neurotrophic_factor gptkb:neurotrophin-3 gptkb:neurotrophin-4 |
| gptkbp:location |
gptkb:cell_membrane
|
| gptkbp:member |
gptkb:NTRK1
gptkb:NTRK2 gptkb:NTRK3 |
| gptkbp:mutationAssociatedWith |
oncogenic fusion proteins
|
| gptkbp:target |
gptkb:TRK_inhibitors
|
| gptkbp:bfsParent |
gptkb:HGNC:9051
gptkb:NTRK3 gptkb:NTRK2_gene gptkb:TrkB_receptor |
| gptkbp:bfsLayer |
8
|