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gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:p140-TrkA
gptkb:Neurotrophic_tyrosine_kinase_receptor_type_1
High affinity nerve growth factor receptor
|
|
gptkbp:associatedWith
|
gptkb:neuroblastoma
gptkb:cancer
gptkb:congenital_insensitivity_to_pain_with_anhidrosis
|
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gptkbp:biologicalProcess
|
cell survival
protein tyrosine kinase activity
axon guidance
neuron differentiation
transmembrane receptor activity
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gptkbp:discoveredBy
|
gptkb:Louis_F._Reichardt
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gptkbp:discoveredIn
|
1986
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gptkbp:encodedBy
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gptkb:NTRK1_gene
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gptkbp:Entrez_Gene_ID
|
ENSG00000198400
|
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gptkbp:expressedIn
|
gptkb:nervous_system
sensory neurons
sympathetic neurons
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gptkbp:family
|
gptkb:Trk_receptor_family
|
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gptkbp:formsComplexWith
|
gptkb:NGF
gptkb:p75NTR
|
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gptkbp:function
|
gptkb:receptor_tyrosine_kinase
mediates effects of nerve growth factor (NGF)
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gptkbp:HGNC_ID
|
8031
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TrkA (human)
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gptkbp:ligand
|
gptkb:nerve_growth_factor_(NGF)
|
|
gptkbp:locatedOnChromosome
|
1q23.1
|
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gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:mutationAssociatedWith
|
gain of function associated with cancer
loss of function causes pain insensitivity
|
|
gptkbp:OMIM
|
191315
|
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gptkbp:organism
|
gptkb:Homo_sapiens
|
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gptkbp:orthologIn
|
gptkb:TrkA_(mouse)
TrkA (rat)
|
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gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:Ras_signaling_pathway
|
|
gptkbp:PDB
|
gptkb:1WWW
4AOJ
|
|
gptkbp:phosphorylates
|
tyrosine residues
|
|
gptkbp:postTranslationalModification
|
phosphorylation
|
|
gptkbp:structure
|
extracellular ligand-binding domain
intracellular tyrosine kinase domain
single transmembrane helix
|
|
gptkbp:target
|
gptkb:crizotinib
gptkb:entrectinib
gptkb:larotrectinib
gptkb:cabozantinib
|
|
gptkbp:UniProtID
|
gptkb:P04629
|
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gptkbp:bfsParent
|
gptkb:TrkA_(mouse)
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gptkbp:bfsLayer
|
8
|