|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:activatedBy
|
ligand binding
|
|
gptkbp:alternativeName
|
gptkb:Neurotrophic_tyrosine_kinase_receptor_type_2
|
|
gptkbp:binds
|
gptkb:BDNF
gptkb:NT-3
gptkb:NT-4
|
|
gptkbp:discoveredBy
|
gptkb:L.F._Parada
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:downstreamOf
|
gptkb:MAPK_pathway
gptkb:PLCĪ³_pathway
gptkb:PI3K-Akt_pathway
|
|
gptkbp:encodedBy
|
gptkb:NTRK2
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:NTRK2
|
|
gptkbp:expressedIn
|
brain
central nervous system
peripheral nervous system
|
|
gptkbp:fullName
|
gptkb:Tropomyosin_receptor_kinase_B
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
binds neurotrophins
|
|
gptkbp:HGNC_ID
|
8032
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TRK B
|
|
gptkbp:involvedIn
|
gptkb:synaptic_plasticity
cell survival
neuronal development
memory formation
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_9q21.33
|
|
gptkbp:memberOf
|
gptkb:TRK_receptor_family
receptor tyrosine kinase family
|
|
gptkbp:mutationAssociatedWith
|
gptkb:neuroblastoma
gptkb:cancer
psychiatric disorders
|
|
gptkbp:OMIM
|
600456
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:phosphorylates
|
tyrosine residues
|
|
gptkbp:relatedTo
|
gptkb:NTRK1
gptkb:NTRK3
gptkb:TRK_A
gptkb:TRK_C
|
|
gptkbp:structure
|
transmembrane domain
extracellular ligand-binding domain
intracellular tyrosine kinase domain
|
|
gptkbp:target
|
gptkb:TRK_inhibitors
antidepressants
|
|
gptkbp:UniProtID
|
gptkb:Q16620
|
|
gptkbp:bfsParent
|
gptkb:entrectinib
gptkb:Entrectinib
|
|
gptkbp:bfsLayer
|
7
|