|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:GP145-TrkC
gptkb:NT-3_growth_factor_receptor
gptkb:TRK-C
gptkb:TRKC
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:congenital_insensitivity_to_pain_with_anhidrosis
congenital heart defects
|
|
gptkbp:biologicalProcess
|
cell differentiation
cell proliferation
cell survival
signal transduction
nervous system development
transmembrane receptor protein tyrosine kinase activity
ATP binding
protein kinase activity
axon guidance
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
integral component of membrane
|
|
gptkbp:discoveredBy
|
1991
|
|
gptkbp:encodes
|
gptkb:TrkC
|
|
gptkbp:Entrez_Gene_ID
|
4915
ENSG00000140538
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:skeletal_muscle
gptkb:kidney
brain
heart
|
|
gptkbp:fullName
|
gptkb:neurotrophic_receptor_tyrosine_kinase_3
|
|
gptkbp:function
|
receptor tyrosine kinase activity
neurotrophin-3 receptor activity
|
|
gptkbp:HGNC_ID
|
8032
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NTRK3
|
|
gptkbp:length
|
825 amino acids
|
|
gptkbp:ligand
|
gptkb:neurotrophin-3_(NT-3)
|
|
gptkbp:locatedOnChromosome
|
15
15q25
|
|
gptkbp:molecularWeight
|
92 kDa
|
|
gptkbp:mutationAssociatedWith
|
oncogenic fusion protein
|
|
gptkbp:OMIM
|
191316
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Ntrk3
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:neurotrophin_signaling_pathway
|
|
gptkbp:PDB
|
gptkb:4AT3
gptkb:4F0K
gptkb:4F0L
gptkb:4F0N
gptkb:4F0P
gptkb:4F0Q
gptkb:4F0R
gptkb:4F0Y
gptkb:4F0Z
gptkb:4F10
gptkb:4F11
gptkb:4F16
gptkb:4F17
gptkb:4F1A
gptkb:4F1B
gptkb:4F1F
gptkb:4F1G
gptkb:4F1H
gptkb:4F1K
gptkb:4F1L
gptkb:4F1M
gptkb:4F1N
gptkb:4F1R
gptkb:4F1X
gptkb:4F1Y
gptkb:4F1Z
4F14
4F19
4F12
4F13
4F15
4F0I
4F0M
4F0O
4F0S
4F0T
4F0U
4F0V
4F0W
4F0X
4F18
4F1C
4F1D
4F1E
4F1I
4F1J
4F1O
4F1P
4F1Q
4F1S
4F1T
4F1U
4F1V
4F1W
|
|
gptkbp:proteinFamily
|
gptkb:neurotrophic_tyrosine_kinase_receptor_family
|
|
gptkbp:UniProtID
|
Q16288
|
|
gptkbp:bfsParent
|
gptkb:TEL2-A
gptkb:larotrectinib
gptkb:NTRK2
|
|
gptkbp:bfsLayer
|
7
|