|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:TRK
gptkb:MTC
gptkb:TRKA
gptkb:p140-TrkA
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:congenital_insensitivity_to_pain_with_anhidrosis
|
|
gptkbp:biologicalProcess
|
cell survival
ATP binding
protein kinase activity
axon guidance
nerve growth factor binding
neuron differentiation
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
integral component of membrane
|
|
gptkbp:discoveredBy
|
gptkb:Mariano_Barbacid
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:encodes
|
gptkb:TrkA_protein
|
|
gptkbp:Entrez_Gene_ID
|
4914
ENSG00000198400
|
|
gptkbp:expressedIn
|
gptkb:nervous_system
gptkb:dorsal_root_ganglia
sympathetic neurons
|
|
gptkbp:fullName
|
gptkb:neurotrophic_receptor_tyrosine_kinase_1
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
gptkb:nerve_growth_factor_receptor
|
|
gptkbp:HGNC_ID
|
HGNC:8031
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NTRK1
|
|
gptkbp:locatedOnChromosome
|
1
1q23.1
|
|
gptkbp:mutationAssociatedWith
|
gptkb:gene
deletion
missense mutation
duplication
nonsense mutation
oncogenic fusion protein
|
|
gptkbp:OMIM
|
191315
|
|
gptkbp:orthologIn
|
gptkb:TrkA_(mouse)
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:product
|
gptkb:TrkA
|
|
gptkbp:proteinFamily
|
gptkb:receptor_tyrosine_kinase
immunoglobulin-like domain
leucine-rich repeat domain
tyrosine kinase domain
|
|
gptkbp:regulates
|
autophosphorylation
activated by NGF
downregulated by ubiquitination
|
|
gptkbp:relatedTo
|
gptkb:neuroblastoma
gptkb:papillary_thyroid_carcinoma
gptkb:cancer
colorectal cancer
glioma
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:target
|
gptkb:entrectinib
gptkb:larotrectinib
gptkb:repotrectinib
|
|
gptkbp:UniProtID
|
gptkb:P04629
|
|
gptkbp:bfsParent
|
gptkb:TrkA
|
|
gptkbp:bfsLayer
|
6
|