Tropomyosin receptor kinase B

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:receptor_tyrosine_kinase gptkb:protein
gptkbp:alternativeName	gptkb:TrkB gptkb:neurotrophic_tyrosine_kinase_receptor_type_2
gptkbp:associatedWith	gptkb:Alzheimer's_disease gptkb:cancer gptkb:depression neurodevelopmental disorders
gptkbp:binds	gptkb:brain-derived_neurotrophic_factor gptkb:neurotrophin-3 gptkb:neurotrophin-4
gptkbp:biologicalProcess	synaptic transmission nervous system development transmembrane receptor protein tyrosine kinase activity axon guidance
gptkbp:encodedBy	gptkb:NTRK2_gene
gptkbp:Entrez_Gene_ID	gptkb:ENSG00000148053
gptkbp:expressedIn	brain peripheral nervous system
gptkbp:foundIn	humans mammals
gptkbp:function	regulates synaptic plasticity regulates neuronal survival regulates neuronal differentiation
gptkbp:GOID	gptkb:GO:0005006
gptkbp:HGNC_ID	8032
https://www.w3.org/2000/01/rdf-schema#label	Tropomyosin receptor kinase B
gptkbp:locatedOnChromosome	gptkb:chromosome_9q21.33
gptkbp:location	gptkb:cell_membrane
gptkbp:mutationAssociatedWith	gptkb:autism_spectrum_disorder gptkb:congenital_insensitivity_to_pain obesity
gptkbp:OMIM	600456
gptkbp:orthologIn	gptkb:mouse gptkb:zebrafish right
gptkbp:PDB	gptkb:1HCF
gptkbp:phosphorylates	autophosphorylation upon ligand binding
gptkbp:structure	single-pass type I membrane protein
gptkbp:target	cancer therapies antidepressant drugs
gptkbp:UniProtID	gptkb:Q16620
gptkbp:bfsParent	gptkb:TrkB
gptkbp:bfsLayer	7