Statements (27)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:associatedWith |
gptkb:cancer
head and neck cancer |
| gptkbp:contains |
zinc finger domains
|
| gptkbp:disrupts |
cell cycle regulation
|
| gptkbp:encodedBy |
HPV genome
|
| gptkbp:firstDescribed |
1980s
|
| gptkbp:foundIn |
gptkb:human_papillomavirus
|
| gptkbp:function |
oncoprotein
|
| https://www.w3.org/2000/01/rdf-schema#label |
E6 (HPV protein)
|
| gptkbp:inhibitedBy |
apoptosis
tumor suppressor pathways |
| gptkbp:interactsWith |
gptkb:p53_protein
E6AP (E6-associated protein) |
| gptkbp:length |
approximately 150 amino acids
|
| gptkbp:locale |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:presentIn |
gptkb:HPV16
gptkb:HPV18 gptkb:high-risk_HPV_types |
| gptkbp:promotion |
degradation of p53
ubiquitination of p53 |
| gptkbp:role |
cellular transformation
immortalization of cells |
| gptkbp:target |
therapeutic research
|
| gptkbp:bfsParent |
gptkb:TP53
|
| gptkbp:bfsLayer |
6
|