Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:discoveredBy |
1990s
|
| gptkbp:domain |
gptkb:BH1
gptkb:BH4 BH3 BH2 |
| gptkbp:enemyOf |
anti-apoptotic BCL2 family proteins
pro-apoptotic BCL2 family proteins |
| gptkbp:foundIn |
animals
humans mammals |
| gptkbp:function |
regulation of apoptosis
|
| gptkbp:hasMember |
gptkb:BOK
gptkb:BAD gptkb:BMF gptkb:MCL1 gptkb:BID gptkb:BAX gptkb:NOXA gptkb:PUMA gptkb:BCL-XL gptkb:BAK gptkb:BCL2 gptkb:BCL2A1 HRK BIM BCL-w BCL2L10 BCL2L12 BCL2L13 |
| https://www.w3.org/2000/01/rdf-schema#label |
BCL2 family proteins
|
| gptkbp:interactsWith |
mitochondrial membrane proteins
|
| gptkbp:involves |
gptkb:cancer
cell survival cell death |
| gptkbp:location |
cytosol
mitochondrial outer membrane |
| gptkbp:mechanismOfAction |
protein-protein interactions
regulation of mitochondrial membrane permeability |
| gptkbp:namedAfter |
gptkb:B-cell_lymphoma_2
|
| gptkbp:proteinFamily |
BCL2 gene family
|
| gptkbp:regulates |
caspase activation
cytochrome c release intrinsic apoptotic pathway |
| gptkbp:role |
anti-apoptotic
pro-apoptotic |
| gptkbp:target |
gptkb:BH3_mimetics
anticancer drugs |
| gptkbp:bfsParent |
gptkb:TP53
|
| gptkbp:bfsLayer |
6
|