tumor necrosis factor alpha (TNF-α)

URI: https://gptkb.org/entity/tumor_necrosis_factor_alpha_(TNF-α)
GPTKB entity
Statements (54)
Predicate Object
gptkbp:instanceOf cytokine
gptkbp:alsoKnownAs gptkb:TNF-α
gptkb:cachectin
gptkbp:discoveredBy gptkb:Lloyd_J._Old
gptkbp:discoveredIn 1975
gptkbp:encodedBy gptkb:TNF_gene
gptkbp:function apoptosis induction
fever induction
induction of inflammation
inhibition of tumorigenesis
regulation of immune cells
https://www.w3.org/2000/01/rdf-schema#label tumor necrosis factor alpha (TNF-α)
gptkbp:involvedIn gptkb:Crohn's_disease
psoriasis
septic shock
rheumatoid arthritis
inflammatory bowel disease
gptkbp:locatedOnChromosome gptkb:6p21.3
gptkbp:membraneBoundForm exists
gptkbp:molecularWeight 17 kDa
gptkbp:producedBy gptkb:natural_killer_cells
gptkb:T_cells
macrophages
gptkbp:recipient gptkb:TNFR1
gptkb:TNFR2
gptkbp:role gptkb:cancer
gptkb:bone
gptkb:systemic_lupus_erythematosus
apoptosis
asthma
tuberculosis
multiple sclerosis
malaria
HIV infection
atherosclerosis
sepsis
autoimmune diseases
cell signaling
immune response
insulin resistance
allergic reactions
cachexia
necrosis
acute phase reaction
gptkbp:secretes soluble protein
gptkbp:structure homotrimer
gptkbp:target gptkb:etanercept
gptkb:infliximab
gptkb:adalimumab
gptkbp:UniProtID gptkb:P01375
gptkbp:bfsParent gptkb:adalimumab_(Humira)
gptkb:TNFRSF1B
gptkb:TNFRSF1B_gene
gptkbp:bfsLayer 8